Vitamin and mineral levels in children with autism spectrum disorder
(1) University of Health Sciences, Bakırköy Dr. Sadi Konuk Research Hospital
(2) University of Health Sciences, Bakırköy Dr. Sadi Konuk Research Hospital
(3) University of Health Sciences, Bakırköy Dr. Sadi Konuk Research Hospital
DOI : https://doi.org/10.23916/0020200528030
Full Text: Language : en
The aim of this study was to compare the vitamin and mineral values of the patients followed up in the Child Psychiatry Outpatient Clinic with the diagnosis of autism spectrum disorder to healthy controls in the same age group and to investigate whether vitamin-mineral values were related to autism weight (CARS score).Between September 2017 and September 2018, we worked at Bakırköy Dr. Sadi Konuk Training and Research Hospital Children and Adolescent Mental Health and Diseases outpatient clinic with autism spectrum disorder patients with childhood autism assessment scale (CARS) was weighted. Age, gender, height, weight, blood Iron, Vitamin B12, Folate and 25 (OH) Vitamin D levels of all patients included in the study were recorded. Mann-Whitney U, Pearson chi-square and Fisher's exact test were used to evaluate the data. In this study, 108 patients with ASD were compared with 115 normal cases. There was no statistically significant decrease in Vitamin B12, Folate, Iron and Vitamin D levels in patients with ASD compared to normal patients. According to CARS score, there was no statistically significant difference in vitamin B12, Folate, Iron and Vitamin D levels in children with mild and severe ASD. In our study, it was concluded that vitamin B12, Folate, Iron and Vitamin D levels in children with ASD were not lower than healthy children, and there was no difference between mild and severe cases according to CARS score.
Association, A. P. Diagnostic and Statistical Manual of Mental Health Disorders: DSM-5. Am. Psychiatr. Publ. Washington, (2013).
Gorrindo P. et al. Gastrointestinal dysfunction in autism: Parental report, clinical evaluation, and associated factors. Autism Res. 5, 101–108 (2012).
Bauman ML. Medical comorbidities in autism: Challenges to diagnosis and treatment. Neurotherapeutics 7, 320–327 (2010).
Buie T. et al. Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report. Pediatrics 125, S1–S18 (2010).
Mouridsen SE, Rich B, Isager T. A longitudinal study of gastrointestinal diseases in individuals diagnosed with infantile autism as children. Child. Care. Health Dev. 36, 437–443 (2010).
Ibrahim SH, Voigt RG, Katusic SK, Weaver AL, Barbaresi WJ. Incidence of Gastrointestinal Symptoms in Children With Autism: A Population-Based Study. Pediatrics 124, 680–686 (2009).
Baio J. et al. Prevalence of Autism Spectrum Disorders in a Total Population Sample-Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014. MMWR Surveill Summ 67, 1–25 (2018).
Nahit Motavallı Mukaddes: Otistik Bozukluk, Çocuk ve Ergen Psikiyatrisi Temel Kitabı HYB 2008: 242-255
Eaves LC, Ho HH. Young adult outcome of autism spectrum disorders. J. Autism Dev. Disord. 38, 739–747 (2008).
Kodak T, Piazza CC. Assessment and Behavioral Treatment of Feeding and Sleeping Disorders in Children with Autism Spectrum Disorders. Child Adolesc. Psychiatr. Clin. N. Am. 17, 887–905 (2008).
Bandini LG. et al. Changes in Food Selectivity in Children with Autism Spectrum Disorder. J. Autism Dev. Disord. 0, 0 (2016).
Herndon AC, DiGuiseppi C, Johnson SL, Leiferman J, Reynolds A. Does nutritional intake differ between children with autism spectrum disorders and children with typical development? J. Autism Dev. Disord. 39, 212–222 (2009).
Graf-Myles J, Farmer C, Thurm A, et al. (2013) Dietary adequacy of children with autism compared to controls and the impact of restricted diet. Journal of Developmental and Behavioral Pediatrics 34(7): 130–134
CurtisLT,PatelK. Ntritional and environmental approaches to preventing and treating autism and attentio deficit hyperactivity disorder (ADHD): a review. J Altern Complement Med 2008;14 (1):79–85. PubMed PMID: 18199019.
Khan NA, Raine LB, Drollette ES, Scudder MR, Hillman CH. The relation of saturated fats and dietary cholesterol to childhood cognitive ﬂexibility. Appetite. 2015;93:51–6.
Khan NA, Raine LB, Drollette ES, Scudder MR, Kramer AF, Hillman CH. Dietary ﬁber is positively associated with cognitive control among prepubertal children. J Nutr. 2015;145:143–9
Özkan B, Rikets. The Journal of Current Pediatrics.2007;3(5):34-41
Xiao Liu, Juan Liu, Xueqin Xiong, Ting Yang, Nali Hou, Xiaohua Liang, Jie Chen, Qian Cheng, and Tingyu Li. Correlation between Nutrition and Symptoms: Nutritional Survey of Children with Autism Spectrum Disorder in Chongqing, China
Kılınç M, Yüregir GT, Ekerbiçer H. Anaemia and iron-deficiency anaemia in south-east Anatolia. Eur J Haematol 2002;69(5-6):280-3.
Gunes et al. Iron deficiency parameters in autism spectrum disorder: clinical correlates an associated factors. Italian Journal of Pediatrics (2017) 43:86
Bener A, Khattab AO, Bhugra D, Hoffmann GF. Iron and vitamin D levels among autism spectrum disorders children. Ann Afr Med 2017;16:186-91
Lozoff B., Jimenez E., Wolf A.W. (1992) ‘Long Term Developmental Outcome of Infants With Iron Deficiency’ New England Journal of Medicine 325:687-94
Otero G.A., Aguirre D.M., Porcayo P., Fernandez T. (1999) ‘Psychological ana Electroencephalogic Study in School Children with Iron Deficiency’ International Journal of Neurosciences 99: 113-21
Bala KA, Dogan M, Mutluer T et al: Plasma amino acid profile in autism spectrum disorder (ASD). Eur Rev Med Pharmacol Sci, 2016; 20: 923–29
Altun H, Kurutaş E.B., Şahin N, Güngör O, Fındıklı E. ‘The Levels of Vitamin D, Vitamin D Receptor, Homocysteine and Complex B Vitamin in Children with Autism Spectrum Disorders’ Clinical Psychopharmacology and Neuroscience 2018;16(4):383-390
Meguid NA, Hashish AF, Anwar M, Sidhom G. Reduced serum levels of 25-hyroxy and 1,25-hyroxy vitamin D in Egyptian children with autism. J Altern Complement Med. 2010 Jun;16(6):6415
Ali, A., Waly, M.I., Al-Farsi, Y.M., Essa, M.M., Al-Sharbati, M.M., & Deth, R.C. (2011). Hyperhomocysteinemia among Omani autistic children: a case-control study. Acta Biochim Pol, 58(4), 547-55
Uğur Ç, Gürkan CK. Serum vitamin D and folate levels in children with autism spectrum disorders. Res Autism Spectr Disord 2014;8:1641-1647.
Esnafoğlu E. Otistik Spektrum Bozukluğu Bulunan Çocuklarda Vitamin B12, Folat ve Vitamin D Seviyelerinin İncelenmesi. Klinik Tıp Aile Hekimliği Dergisi Cilt: 9 Sayı: 4 Temmuz - Ağustos 2017
Kauna-Czapli ska J, urawicz E, Michalska M, Rynkowski J. A focus on homocysteine in autism. Acta Biochim Pol 2013;60(2):137-142
Puig-Alcaraz C, Fuentes-Albero M, Calderón J, Garrote D, Cauli O. Increased homocysteine levels correlate with the communication deficit in children with autism spectrum disorder. Psychiatry research 2015;229(3):1031-1037
Mostafa, G. A., & Al-Ayadhi, L. Y. (2012). Reduced serum concentrations of 25-hydroxy vitamin D in children with autism: Relation to autoimmunity. Journal of Neuroinflammation, 9, 201
Afaf El-Ansary, Geir Bjørklund, Asma M. Khemakhem, Laila Al-Ayadhi, Salvatore Chirumbolo, Abir Ben Bach. Metabolism-Associated Markers and Childhood Autism Rating Scales (CARS) as a Measure of Autism Severity. Journal of Molecular Neuroscience (2018) 65:265–276
Gong, Z. L., Luo, C. M., Wang, L., Shen, L., Wei, F., Tong, R. J., et al. (2014). Serum 25-hydroxyvitamin D levels in Chinese children with autism spectrum disorders. Neuroreport, 25, 23–27.
Hashemzadeh M, Moharreri F, Soltanifar A. Comparative study of vitamin D levels in children with autism spectrum disorder and normal children: A case-control study. Journal of Fundamentals of Mental Health 2015 July-Aug; 17(4): 197-201.
Article MetricsAbstract Views : 322 times
PDF Downloaded : 16 times
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution 4.0 International License.